中文名称:[5-溴-3-[(1R)-(2,6-二氯-3-氟苯基)乙氧基]吡啶-2-基]胺
中文同义词:[5-溴-3-[(1R)-(2,6-二氯-3-氟苯基)乙氧基]吡啶-2-基]胺((R)-5-BROMO-3-(1-(2,6-DICHLORO-3-FLUOROPHENYL)ETHOXY)PYRIDIN-2-AMINE);克里唑蒂尼中间体Ⅰ[5-溴-3-[(1R)-(2,6-二氯-3-氟苯基)乙氧基]吡啶-2-基]胺;3-[(1R)-(2,6-二氯-3-氟苯基)乙氧基]-2-氨基-5-溴吡啶;[5-溴-3-[(1R)-(2,6-二氯-3-氟苯基)乙氧基]吡啶-2-基]胺(克唑替尼中间体1);(R)-5-溴-3-(1-(2,6-二氯-3-氟苯基)甲氧基)吡啶-2-胺;(克唑替尼中间体3)[5-溴-3-[(1R)-(2,6-二氯-3-氟苯基)乙氧基]吡啶-2-基]胺;克唑替尼杂质C;克唑替尼中间体[5-溴-3-[(1R)-(2,6-二氯-3-氟苯基)乙氧基]吡啶-2-基]胺
英文名称:(R)-5-bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyrChemicalbookidin-2-amine
英文同义词:InterMediateⅠofCrizotinib(R)-5-broMo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-aMine;2-PyridinaMine,5-broMo-3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-;Crizotinib-H;5-bromo-3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridin-2-amine;(R)-5-bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)yridine-2-amine;Chiralintermediateofcrizotinib;Crizotinibintermediates1;(R)-5-bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine
CAS号:877399-00-3
分子式:C13H10BrCl2FN2O
分子量:380
应用：[5-溴-3-[(1R)-(2,6-二氯-3-氟苯基)乙氧基]吡啶-2-基]胺在化工医药研发过程中可用作克唑替尼中间体，克唑替尼用于治疗间变性淋巴瘤激酶(ALK)阳Chemicalbook性的局部晚期和转移的非小细胞肺癌(NSCLC)。克唑替尼治疗ALK阳性的非小细胞肺癌客观缓解率达60%，无进展生存期为8-10个月，相比于化疗显著改善并延长的总生存期。
